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        1. CATALYTIC CO2 REDUCTION BY PALLADIUM
          DECORATED SILICON HYDRIDE NANOSHEETS
          The Ozin Group shows how decorating silicon nonosheets with palladium
          nanoparticles renders the process catalytic, a breakthrough with far
          reaching technological implications.
          Ozin group, Nature Catalysis, 2019
        2. UNUSUAL REARRANGEMENT OF AN
          N-DONOR-FUNCTIONALIZED N-HETEROCYCLIC
          CARBENE LIGAND ON GROUP 8 METALS
          The Song group discovered an unusual rearrangement reaction,where
          the N,C-chelate ligand of a piano-stool Group 8complex isomerizes into
          an N,N-chelate ligand. Mechanistic study suggests the involvement of a
          high-energy metal-alkylidene intermediate.
          Song group, Journal of the American Chemical Society, 2018
        3. DYSREGULATION OF MITOCHONDRIAL CLPP
          PROTEASE AS A POTENTIAL STRATEGY TO
          DEVELOP NOVEL ANTICANCERS
          Human mitochondrial ClpP was found to be activated by specific
          acyldepsipeptide compounds causing apoptotic cell death.
          Houry and Batey groups, Cell Chemical Biology, 2018
        4. AMINE HEMILABILITY ENABLES BORON TO
          MECHANISTICALLY RESEMBLE EITHER
          HYDRIDE OR PROTON
          Mechanistic studies of the hemilability of MIDA
          (N-methyliminodiacetic acid) boronates reveal the chameleonic
          behaviour of the BMIDA group.
          Yudin group, Nature Chemistry, 2018
        5. TIPPING CELL SIGNALING PATHWAYS BY SALTS
          Mechanistic insights into allosteric regulation ofthe A2A adenosine
          G protein-coupled receptor byphysiological cations.
          Prosser group, Nature Communications, 2018
        6. COMPETITIVE SELF-ASSEMBLY KINETICS AS A
          ROUTE TO CONTROLLING MORPHOLOGY OF
          CORE-CRYSTALLINE CYLINDRICAL MICELLESS
          One can manipulate the seeded-growth kinetics of block
          copolymer unimers to control the growth sequence of
          unimers and thus the comicelle morphology.
          Winnik group, Journal of the American Chemical Society, 2018
        7. INHIBITING MYC BINDING TO THE E-BOX DNA
          MOTIF BY ME47 DECREASES
          TUMOUR XENOGRAFT GROWTH
          The Shin lab's designed protein ME47 decreased tumor growth in
          a triple negative breast cancer mouse model, a type of cancer with
          no effective treatments.
          Shin, Chan & Penn groups, Oncogene, 2017

        Awards:

        Chris Caputo awarded 2018 Polanyi Prize

        Congratulations to Chris Caputo (PhD '15, Stephan Group) for being one of five Ontario researchers honoured in the 2018 Polanyi Prizes.

        Chris is being recognized for research that focuses on how to use “main group?chemicals ?common, non-metal elements such as boron and phosphorous ? to take their place as catalysts. This means manipulating them to create molecules that can mimic the high reactivity of precious metals.


        News and Announcements:

        Startup from the lab of Professor Molly Shoichet raises $3.25 million to eliminate prescription opioids after surgery

        A U of T startup has raised $3.25 million to develop a gel-based drug delivery system that could eliminate the need to give patients powerful painkillers following surgery ?a key source of the current opioid crisis.

        The startup, AmacaThera, is built on a gel technology developed in the lab of Professor Molly Shoichet that dramatically extends the duration of anesthetics injected at the site of a surgical incision.


        Professor Geoff Ozin: 'The story of CO2 needs altering'

        Professor Geoff Ozin writes in Advanced Science News about the "rapid dissemination of misleading, confusing, frightening and false information" in science, particularly when it relates to carbon dioxide.

        "By regarding CO2 as a friend rather than a foe, to see it as a recyclable feedstock for making value-added products, rather than a polluting waste, people can begin to appreciate how it could actually prevent the next mass extinction of life on earth, rather than being the cause."


        Professor Andrei Yudin appointed as Associate Editor at Chemical Science

        Professor Andrei Yudin has been named Associate Editor at Chemical Science.

        Professor Yudin will handle submissions in the areas of organic synthesis, transition metal catalysis, peptide preparation and macrocyclisation.






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